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Chabner Colloquium 2015

October 26 - 27, 2015
The Liberty Hotel, Boston, MA. (map)
Program Brochure (PDF)
Abstract Book (PDF)

Session 1:
New Therapeutic Approaches: Immunotherapy and Cancer Sanctuaries

CAR Therapy—The CD19 Paradigm Michel Sadelain, MD, PhD Summary (PDF)
Cancer Vaccines and Immunomodulatory TherapyDavid E. Avigan, MDSummary (PDF)
31:02

Genomic Characterization of CNS Metastases: Implications for Precision MedicinePriscilla K. Brastianos, MDSummary (PDF) | Video

Session 2: Exploiting Defective DNA Repair

39:44

The "BRCA-Like" Phenotype in CancerLeif W. Ellisen, MD, PhDSummary (PDF) | Video

Targeting DNA Repair in Cancer Therapy Alan D. D'Andrea, MD Summary (PDF)
39:34

Alternative Lengthening of Telomeres Renders Cancer Cells Hypersensitive to ATR InhibitorsLee Zou, PhDSummary (PDF) | Video

Session 3: New Concepts in Cancer Biology

Reengineering the Tumor Stroma to Improve Cancer Treatment:Bench to Bedside Rakesh K. Jain, PhD Summary (PDF)
Targeting Sleeping Cancer Cells Sridhar Ramaswamy, MD Summary (PDF)
Deconstructing Breast Cancer from a Developmental Perspective Geoffrey M. Wahl, PhD Summary (PDF)
Session 4: Rising Stars Forum

16:13

The Lazarex-MGH Cancer Care Equity ProgramRyan Nipp, MDSummary (PDF) | Video

21:02

Preferentially Targeting the Malignant Hematopoietic Clone in Myeloproliferative Neoplasms (MPN)Ann Mullally, MDSummary (PDF) | Video

18:06

Molecular Analysis of CTCs in Prostate CancerDavid T. Miyamoto, MD, PhDSummary (PDF) | Video

15:47

Loss of SIRT6 Reactivates the Oncofetal Protein Lin28b to Drive Pancreatic CancerSita Kugel, PhDSummary (PDF) | Video

Session 5: Metabolic and Signaling Pathways

Serine Biosynthesis Regulates Folate Availability in Cancer Cells Matthew Vander Heiden, MD, PhD Summary (PDF)
42:00

Monitoring Cancer Through Circulating Tumor CellsDaniel A. Haber, MD, PhDSummary (PDF) | Video

47:42

Emerging Therapies to Optimize MAP Kinase Blockade and Intercept Compensatory SignalingKeith T. Flaherty, MDSummary (PDF) | Video

Session 6: Clinical Drug Development

35:05

Oncology Drug Development in the Era of Precision Medicine: FDA PerspectiveGideon M. Blumenthal, MDSummary (PDF) | Video

39:09

The Changing Nature of Phase I TrialsLillian Siu, MD, FRCRCSummary (PDF) | Video

How Financial Engineering Can Cure Cancer Andrew W. Lo Summary (PDF)
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Chabner Colloquium 2014

November 10-11, 2014
Program Brochure (PDF)
Abstract Book (PDF)

Video Presentations
58:11

Lessons From the Study of Extraordinary RespondersDavid B. Solit, MDVideo

57:56

Advances in Molecular Screening NGSA. John Iafrate, MD, PhDVideo

31:01

Exploiting Methylthioadenosine Phosphorylase Deficiency in CancerJoseph R. Bertino, MDVideo

19:31

Late Breaking Advances-RNF43 Mutations in Colon CancerMarios Giannakis, MD, PhDVideo

32:21

Improving Outcome From Sporadic CRPC: Targeting PARPJohann Sebastian de Bono, MD, PhDVideo

16:12

EZH2 Inhibition in SWI/SNF Altered SarcomasGregory M. Cote, MD, PhDVideo

58:24

Curative Potential of Cell Transfer Immunotherapy for CancerSteven A. Rosenberg, MD, PhDVideo

43:55

The Histone Deacetylase SIRT6: Linking Epigenetics to Cancer MetabolismRaul Mostoslavsky, MD, PhDVideo

17:06

Molecular Interrogation of Circulating Tumor Cells for Drug Development in Breast CancerAditya Bardia, MD, MPHVideo

43:50

Molecular Profile of Acute Myeloid Leukemia (AML)Timothy A. Graubert, MDVideo

43:08

Pathogenesis and Therapy of IDH-TET-Mutant Myeloid MalignanciesRoss L. Levine, MDVideo

46:46

Understanding Myelodysplastic Syndromes (MDS)Benjamin L. Ebert, MDVideo

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Chabner Colloquium 2013

October 28-29, 2013

Video Presentations

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Chabner Colloquium 2012

November 5-6, 2012

Video Presentations

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Chabner Colloquium 2011

October 24-25, 2011

Video Presentations

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