Optimizing molecular testing in cancer care requires access to reliable resources and best practice guidelines. The Incorporating Molecular Testing to Support Personalized Cancer Care toolkit is designed to support healthcare professionals by providing essential references and educational materials. Developed as part of a three-part program informed by an MD Anderson Cancer Network™ Performance Improvement and Quality Improvement (PI/QI) initiative, this toolkit offers updated guidelines, patient communication strategies, and foundational education on PI/QI.