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CHABNER COLLOQUIA

ANSWERING THE BIG QUESTIONS IN CANCER RESEARCH

NEW TARGETS, BIOMARKERS, TECHNOLOGIES, AND PATHWAYS FOR THERAPY

Overview
Chair: Bruce A. Chabner, MD

This annual Colloquium is held in collaboration with The Massachusetts General Hospital Cancer Center and designed to focus on topics that bring cancer biology to clinical application:

  • New targets and targeted agents
  • Strategies for profiling and selection of patients for targeted drug trials
  • Biomarkers and animal models to guide clinical development


CHABNER COLLOQUIUM 2018

Session 1:
Novel Targets and Biomarkers


(Overview) Beyond PARP1: Ribosylation as a Target for Cancer Therapy
Victoria Richon, PhD
Ribon Therapeutics

Full Lecture: Audio|Slides



(Overview) Melanoma: Clues to Improved Therapeutic Efficacy from Disease Pathogenesis
David E. Fisher, MD, PhD
Massachusetts General Hospital



(Overview) Targeting Cell Death Pathways with Precision Using Functional Assays
Anthony Letai, MD, PhD
Dana-Farber Cancer Institute

Full Lecture: Audio|Slides


Session 2:
Enhanced Technology for Early Detection of Cancer


(Overview) Microfluidics for the Characterization of Tumor-specific Extracellular Vesicles
Shannon Stott, PhD
Massachusetts General Hospital

Full Lecture: Audio|Slides



(Overview) Clinical Application of Liquid Biopsies and Genotypedirected
Targeted Therapies for Metastatic Breast Cancer

Aditya Bardia, MD, MPH
Massachusetts General Hospital

Full Lecture: Audio|Slides


Digital RNA-based Analysis of Circulating Tumor Cells for Noninvasive Monitoring of Cancer
Daniel Haber, MD, PhD
Massachusetts General Hospital

Full Lecture: Audio|Slides


Session 3:
Progress in Immunotherapy


(Overview) CAR-T Cell Therapy of Ovarian Cancer
Oladapo Yeku, MD, PhD
Massachusetts General Hospital

Full Lecture: Audio|Slides



(Overview) Molecular Tumor Board: Resistance to Checkpoint Inhibitors Part 1
David Liu, MD, MPH
Massachusetts General Hospital



(Overview) Molecular Tumor Board: Resistance to Checkpoint Inhibitors Part 2
Ryan Sullivan, MD
Massachusetts General Hospital



Full Lecture: Part 1|Part 2|Slides


Session 4:
Junior Faculty Forum

(Overview) The Neoadjuvant Model as a Translational Tool for Drug and Biomarker Development in Breast Cancer
Laura M. Spring, MD
Massachusetts General Hospital

Full Lecture: Audio|Slides



(Overview) Clinical Utility of Longitudinal Molecular Profiling for
Management of ALK-Positive Lung Cancer

Ibiayi Dagogo-Jack, MD
Massachusetts General Hospital

Full Lecture: Audio|Slides



(Overview) New Biomarkers in a Novel Antibody-drug Conjugate for Triple Negative Breast Cancer
Aiko Nagayama, MD, PhD
Massachusetts General Hospital

Full Lecture: Audio|Slides



(Overview) Lin28B, a Promoter of Metastasis and Drug Resistance
Joseph Franses, MD, PhD
Massachusetts General Hospital

Full Lecture: Audio|Slides


2018 Acknowledgments

The Society for Translational Oncology gratefully acknowledges educational grants in partial support of this activity from:

Amgen, Inc.
Celgene
EMD Serono, Inc.
Janssen R&D, LLC
Novartis Pharmaceuticals Corp.

For funding opportunities, please contact Melissa Cather at 617-593-5588 or melissa.cather@sto-online.org.